Welcome Debbie's Dream Foundation: Curing Stomach Cancer
Debbie's Dream Foundation: Curing Stomach Cancer is dedicated to raising awareness about stomach cancer, advancing funding for research, and providing education and support internationally to patients, families, and caregivers. DDF seeks as its ultimate goal to make the cure for stomach cancer a reality. Visit our Contact Us Page
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October 29, 2014 - FOLFIRI May be Viable First-Line Regimen for Advanced Gastric, EsophagoGastric Junction Adenocarcinoma

Patients with advanced gastric and esophagogastric junction adenocarcinoma who underwent first-line treatment with fluorouracil, leucovorin and irinotecan demonstrated significantly longer time to treatment failure than those treated with epirubicin, cisplatin and capecitabine, according to results of a randomized phase 3 study.

October 28, 2014 - Helicobacter pylori vaccine

ImevaX GmbH announced today that they will be funding a clinical trial of IMX 101, which is a highly specific vaccine against Helicobacter pylori (H. pylori). Chronic infections of the stomach with H. pylori are the most common bacterial infections worldwide and lead to gastritis, stomach ulcers and potentially stomach cancer. Due to the high global infection rate and the decreasing efficacy of existing antibiotics against H. pylori plus the poor safety profile of these treatments, there exists a high medical need and a significant commercial interest in a H. pylori vaccine.

October 24, 2014 - More Focus on H Pylori and Gastric Cancer Needed

Though uncertainties remain, gastric cancer and Helicobacter pylori represent an enormous opportunity for prevention. An amazing 770,000 out of 989,000 total gastric cancer cases around the world in 2008 can be attributed to the bacterial infection, suggesting that eradication could yield drastic reductions in incidence. Estimates suggest 700,000 people will die of gastric cancer this year, making it the third-most common cause of cancer deaths around the world.

October 5, 2014 - Green Tea Could Help Scientists Develop New Cancer Fighting Drugs

Scientists believe green tea could be used to develop new drugs to fight cancer.  Green tea is made up of a class of chemicals called catechins, the most abundant of which is EGCG (Epigallocatechin Gallate).  Dr Joo Eun Chung and his colleagues have shown that the anticancer protein Herceptin can combine with EGCG to form a stable and effective complex to deliver a drug to a tumor site.

September 28, 2014 - Merck Drug Extends Immune System Fight to Stomach Cancer

Merck & Co's drug Keytruda, the first in a new wave of immune-boosting medicines to be approved for treating melanomas in the United States, also has potential in stomach cancer, new research shows. Early clinical trial results reported on Sunday mean that gastric, or stomach cancer, can be added to a growing list of tumor types where so-called immunotherapy may have an important role to play.

September 26, 2014 - Treating an infection to prevent a cancer: H. pylori and stomach cancer

Nearly 11,000 Americans will likely die from gastric cancer this year, with only 28 percent of cases surviving five years or more. About 77 percent of gastric cancer cases are linked to chronic infections of Helicobacter pylori, a helix-shaped bacteria that was identified in the early 1980s and found to be linked to gastric ulcers a few years later, as well as to gastritis, an inflammation of the stomach lining that is a precursor to stomach cancer. Screening and treatment for H pylori is generally acceptable and affordable. An inexpensive serological test can determine who may be infected, with a sensitivity and specificity that could be sufficient for population-based prevention programs.

September 8, 2014 - Prediabetic Patients May Face Higher Risk for Stomach Cancer

Having too much sugar in your blood, even if you are not diabetic, is considered unhealthy and there may be an association between having high blood sugar levels and developing a serious health condition.  Past research has suggested a possible link between prediabetes and cancer.  The cancers most associated with prediabetes were liver, stomach/colorectal and uterine (endometrial) cancers.  Talk to a dietician about ways to improve your diet. For more information on nutrition visit:

September 1, 2014 - Increased Helicobacter Pylori is Mediated by Spermine Oxidase

Helicobacter pylori infection causes gastric cancer, the third leading cause of cancer death worldwide.  More than half of the world's population is infected.  Clinical trials suggest that antibiotic treatment only reduces gastric cancer risk in patients with non-atrophic gastritis (NAG), and is ineffective once preneoplastic lesions of multifocal atrophic gastritis (MAG) and intestinal metaplasia (IM) have occurred. Polyamines, generated by the rate-limiting enzyme ornithine decarboxylase (ODC), in gastric carcinogenesis have been used as an additional strategy.

August 29, 2014 - Severing Nerves May Shrink Stomach Cancers

Research from Columbia University Medical Center shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox could be an effective treatment for the disease. The study was conducted by the laboratory of Timothy C. Wang, MD, in collaboration with Duan Chen, MD, PhD, in Norway and is published in an August issue of Science Translational Medicine. Using three different mouse models of stomach cancer, Dr. Wang's team found that when they performed a procedure called a vagotomy to cut the nerves, the surgery significantly slowed tumor growth and increased survival rates.

August 26, 2014 - Botox 'Highly Effective' Treatment of Gastric Cancer

In laboratory tests, Botox - made from the toxin of botulism bacteria - proved "highly effective" at suppressing gastric cancer in mice. The promising results have led to the launch of an early clinical trial involving human patients with stomach cancer in Norway. Botox injections are less toxic than most standard cancer treatments, caused hardly any side effects, and are relatively cheap.

August 24, 2014 - Drug of Choice

One of the cheapest drugs in the world is perhaps the most single effective agent in helping populations stay alive. The drug is aspirin. Aspirin can help with cardiovascular risk, stopping cancer, and the risk of bleeding among other things. Esophageal and stomach cancer rates were cut by thirty percent.  Also, the death rate reduction exceeded the reduction in tumor incidence. That means the people who did get these tumors, if they were taking aspirin, lived longer.

August 10, 2014 - Results Demonstrate 'Ongoing Need For Improvement' In Gastric Cancer Treatment

Controversy about the required radicality of surgery in the curative treatment of gastric cancer has lessened in recent years.  There is not a nearly global consensus that D2 lymphadenectomy represents the optimal surgery for gastric cancer. Read more on this article written by DDFs Medical Advisory Board Member, Dr. David Ilson.

August 8, 2014 - Cancer Should Be Classified By Genetic and Molecular Type

A research network in the US proposes that cancer should be classified according to genetic and molecular features rather than by the type of tissue in which the tumor arises. Scientists say that such a system would be better for patients because it would help tailor treatment to their individual needs. Medical News Today recently reported another TCGA study that found four distinct molecular subtypes of stomach cancer.

August 6, 2014 - Daily Aspirin Cuts Bowel and Stomach Cancer Deaths

Scientists have found that taking aspirin daily can significantly reduce the risk of developing, and dying from, the major cancers of the digestive tract, such as bowel, stomach and oesophageal cancer. Rates of oesophageal and stomach cancers were cut by 30 percent and deaths from these cancers by 35-50 percent according to the researchers led by Professor Jack Cuzick, Head of QMUL's Centre for Cancer Prevention.

August 5, 2014 - DNA Work Offers Stomach Cancer Hope

Doctors from the University of Hong Kong have mapped the world's most comprehensive DNA database showing hundreds of genetic mutations in stomach cancer. The DNA mapping could help develop "targeted" drugs for the disease.  Curretly there is only one such targeted drug, Herceptin, available to treat stomach cancer.  The university team has identified hudreds of driver genes causing the disease.

July 30, 2014 - TCGA Identifies Four Gastric Cancer Subtypes

Researchers of The Cancer Genome Atlas Research Network have found that gastric adenocarcinomas can be divided into four distinct groups: tumors that are positive for Epstein-Barr Virus; microsatellite unstable unstable tumors; genomically stable tumors; and tumors with chromosomal instability. The researchers, led by Adam Bass, MD, of Dana-Farber Cancer Institute in Boston, obtained samples of adenocarcinoma from 295 patients who had not been treated with prior chemotherapy or radiotherapy. They conducted a variety of genomic analyses, including whole genomic sequencing on 107 tumor/germline pairs. Bass says that a key advance in this project is the development of a much more useful classification system, which will allow doctors to pursue key targets in different groups of patients.

July 25, 2014 - MGr1-Ag/37LRP Promotes Growth and Proliferation of Gastric Cancer in Vitro and in Vivo

Gastric carcinoma (GC) is an aggressive cancer due to the MGr1-Ag cells that make up the many tissues of the stomach. MGr1-Ag was originally thought to resist the many drugs used to combat this lethal cancer. Since the MGr1-Ag is very common in GC tissues and not healthy tissues, the outlook looked grim. However, recent studies suggest that tumor growth is dependent on a certain region within the MGr1-Ag and the knockdown of this certain type of cell leads to decreased GC cell growth in vivo and in vitro. These studies can potentially be used as a prognostic factor and a therapeutic target for GC.

July 23, 2014 - Debbie's Dream Foundation Continues to Be at the Forefront of Hastening Stomach Cancer Treatment Development and Assisting with Clinical Trials Enrollment

Debbie's Dream Foundation is contributing to the fight against stomach cancer on many fronts. We are very proud of our DDF Medical Advisory Board Member Adam Bass and his leadership on the TCGA Gastric Cancer Project. This project is a federally funded initiative that involves large international groups of researchers and centers that are cataloging genomic characteristics in gastric (stomach) cancer. The project, which announced its findings in Nature today, found that there are four main subtypes of stomach cancer. This revolutionary finding of gastric cancer subtypes is expected to lead to quicker improvements in the diagnosis, treatment and prevention of stomach cancer.

July 17, 2014 - Local Scientists Find Out What Turns Stomach Cells Cancerous

Instead of carrying cancer-causing mutations in genes, researchers in Singapore found that stomach cancer cells have normal genes that are being abnormally activated, which causes the cells to turn cancerous.  Using the latest DNA sequencing technologies developed at their institute, the tumor cells are comprehensively analyzed to identify molecular differences between cancer cells and normal tissue.  Data from the World Health Organization showed that stomach cancer is a major cause of cancer death worldwide.

July 15, 2014 - Assessing the ‘Fit' Older Patient for Chemotherapy

Making appropriate treatment decisions for older adults with cancer is one of the most important challenges that oncologists face in daily practice, as the therapy selected depends on an assessment of the patient's "fitness."  In this article you will find specific considerations for evaluating patients who appear to be "fit" for chemotherapy treatment, and outline methods for integrating the principles of geriatric medicine to form a clear picture of an older adult's level of fitness and thus his or her individual risk of significant toxicity from cancer therapy.

July 14, 2014 - 5 Eating Habits That Can End In Stomach Cancer

Here are five unhealthy diets that can make us vulnerable to stomach cancer: irregular diet, hot and stimulating foods, 'distracted diet', rice soaked with soup, and acidic fruit on an empty stomach. People who have irregular diets suffer 1.3 times the incidence of stomach cancer than those who eat at a fixed time. Hot food increases the risk of the stomach cancer by 4.22 times. Suggestions offered by medical experts are that it would help if we get up 15 to 20 minutes earlier and focus on breakfast, rather than to eat on the go. Eating rice that has been soaked with soup increases the burden in the stomach since the rice has been swallowed whole. When we are hungry, gastric acid in the stomach will reach a high concentration, which, if combined with fruit, will precipitate in the stomach.

July 10, 2014 - Phase I Trial for BeiGene's PARP Inhibitor Begins

The first patient has been dosed in the Phase I trial of BGB-290 for cancer treatment.  BGB-290 is an inhibitor of PARP, an enzyme that is involved in multiple cell processes.  Small molecules of BGB-290 have shown to fight tumors by picking up and trapping PARP proteins on damaged DNA. Anti-tumor effects have been exhibited and could become a treatment option for common cancers.

July 4, 2014 - Researchers Discover Novel Protein Complex with Potential to Combat Gastric Cancer Caused By Bacterial Infection

Scientists from the Cancer Science Institute of Singapore (CSI Singapore) discovered that a protein named IL23A is part of our stomach's defense against bacterial infection which leads to gastric cancer. This finding could potentially be used to combat the deadly disease. In Singapore, stomach cancer was the fourth leading cause of cancer death among men and fifth among women from 2008 to 2012. This highlights the urgent need to understand the causes of this deadly disease.

July 2, 2014 - Apatinib Prolongs Survival in Advanced Gastric Cancer

Apatinib significantly improved overall survival according to the results of a phase III study presented at the 2014 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago. Results of the study revealed an almost 2-month overall survival advantage for patients assigned to treatment with apatinib. Treatment with apatinib was generally well tolerated and the main side effects consisted of low white blood cell counts, low platelet counts and toxicity to the skin know as hand-foot syndrome.

June 28, 2014 - Dr. Bendell Discusses a Phase III Study of Apatinib in Gastric Cancer

Johanna Bendell, MD, director of GI Cancer Research Program discusses a randomized phase III placebo-controlled trial that explored apatinib as a treatment for patients with advanced gastric cancer. During the trial, the drug was studied in Chinese patients as second-line therapy for patients with metastatic gastric cancer. The study found that there was a statistically significant improvement in overall survival in the apatinib arm versus the placebo arm, Bendell says.

June 27, 2014 - Ramucirumab Benefit for US Patients With Gastric Cancer Mirrors Global Results

Patients in the United States and other Western nations experienced similar survival gains and adverse events as did their counterparts in two other regions of the world from the use of ramucirumab (Cyramza) in advanced gastric cancer. Eli Lilly and Company, which developed the drug, supported this geographic analysis of clinical trial results.

June 25, 2014 - Advaxis Gets Allowance from USPTO for Two Cancer Immunotherapy Patent Applications

ADXS-cHER2 is being developed to target the Her2 receptor, which is overexpressed in certain solid-tumor cancers, including bone cancer (osteosarcoma), breast cancer, esophageal and gastric cancer.  Advaxis, a United States based clinical-stage biotechnology firm is planning to start a Phase I trial with ADXS-cHER2 in pediatric osteosarcoma, for which it received orphan drug designation, and is pursuing early development clinical collaborations for breast, esophageal and gastric cancers.

June 25, 2014 - Nigeria: Heartburn Can Lead to Ulcers, Stomach Cancer

Gastro-Esophageal Reflux Disease (GERD), also referred to as heart burn, has been warned as a serious medical condition according to Nigerian medical experts. Apart from discomfort and pain associated with the condition, it can eventually lead to ulcers, stomach cancer and cancer of the oesophagus.

June 25, 2014 - Diet Poses Big Cancer Risk

Your diet says a lot about your future.  Among the top 10 cancers that threaten Chinese people's health, five are cancers of the digestive system, including esophageal cancer, gastric cancer and colorectal cancer.  Experts remind citizens to change their unhealthy dietary patterns and eat more fruits and vegetables, the Beijing Morning Post reported.  What are you eating?

June 24, 2014 - Stomach Cancer Treatment Advances at Memorial Sloan Kettering

Memorial Sloan Kettering is one of the leading cancer centers in the United States for diagnosing and treating patients with stomach cancer.  Their effectiveness in treating this disease has been enhanced by the ability to identify subtle but important differences among various types of stomach cancer and to accurately stage the condition so that they can determine the best treatment approach.  Memorial Sloan Kettering's multidisciplinary team of more than 20 doctors includes world-class specialists in gastroenterology, surgical oncology, medical oncology, interventional radiology, and radiation oncology who work closely together to diagnose and treat this illness.

June 23, 2014 - H.Pylori is the deadliest thing you've never heard of — here's why you should be screened for it

Helicobacter Pylori (H.Pylori) is a common bacterial infection of the lining of the stomach. H.Pylori often causes no symptoms but is associated with a number of significant conditions such as stomach cancer. It is estimated that 2500 new cases of stomach cancer occurring within the UK each year are linked to the presence of H.Pylori infection. Screening for H.Pylori, perhaps as part of a full health check or health assessment, can reduce the risk of developing stomach cancer by one-third. Ask your doctor at your next visit!

June 20, 2014 - Cancer Patients May 'Feel Drunk' From Docetaxel, Says FDA

The commonly used intravenous chemotherapy docetaxel "may cause patients to experience intoxication or feel drunk during and after treatment," warns the US Food and Drug Administration (FDA). The FDA is revising the labels of all docetaxel products to warn about the risk for intoxication.  Docetaxel is used in the treatment of cancers of the breast, prostate, stomach, head and neck, and lung.

June 16, 2014 - Basket Design: A Novel Approach to Cancer Clinical Trials

The growing understanding of cancer biology has demanded that the design of cancer clinical trials evolves as well. One example of this is the "basket trial" design mentioned numerous times throughout the ASCO 2014 meeting. This novel study design attempts to match patients with a rare mutation, regardless of tumor histology, to a drug expected to work through the mutated pathway.

June 14, 2014 - Genetic mutation behind inherited stomach cancer

A genetic mutation was discovered by researchers at Otago University, led by Parry Guilford, that is linked to inherited stomach cancer.  The gene is rare, known in only about 350 families worldwide.  Once the gene is found, one must decide whether to live with the mutation or to have their stomach removed by total gastrectomy.

June 13, 2014 - June is Men's Health Month

Celebrate every June, Men's Health Month! Men's Health Month is celebrated across the country with screenings, health fairs, media appearances, and other health education and outreach activities.  55 percent of men have not seen their doctor in the past year, and men make half as many doctors visits for prevention as women.  Lets celebrate this month of awareness for men's health!

June 10, 2014 - Immune Protein Could Fight Gastric Cancer

In recent gastric cancer studies, scientists have found that a protein called IL23A could help in the fight against stomach cancer. This protein is secreted by white blood cells in response the bacterial infection H. pylori. However, IL23A can only be expressed if RUNX3,a tumor suppressor gene, is present. In gastric cancer patients this gene is commonly suppressed. However, by tapping into RUNX3's potential, IL23A could help in the fight against stomach cancer.

June 10, 2014 - Cancer Council takes aim at lesser-known killers such as stomach cancer

The Cancer Council plans to shine the spotlight on the­ ­"forgotten cancers" such as stomach, liver, and pancreas cancer. These cancers are responsible for more than half of all cancer deaths in Australia.  The Cancer Council's Forgotten Cancers Project will look into the causes of less common cancers and try to increase early detection and survival rates.

June 5, 2014 - FOLFOX Plus Ramucirumab Fails to Improve PFS in Gastric, Esophageal Cancer

A phase II trial was presented at the 2014 American Society of Clinical Oncology (ASCO) Annual Meeting showing that adding ramucirumab to FOLFOX did not delay progression in patients with untreated advanced gastric or esophageal adenocarcinoma. However, the anti-VEGFR2 monoclonal antibody was found to improve disease control rate, and to provide a longer progression-free survival in a subgroup of patients with gastric or gastroesophageal junction adenocarcinoma.

June 3, 2014 - Chinese Study on Advanced Gastric Cancer Cure Wins American Award

Every year around 952,000 new gastric cancer cases are diagnosed worldwide and 47 percent of those are in China. 60 to 80 percent of those diagnosed are diagnosed at a late stage, which leaves them with very limited treatment options. Chinese doctors have recently won an award for their new study on the treatment of advanced gastric cancer which they presented at the American Society of Clinical Oncology (ASCO) in Illinois.

June 3, 2014 - Red meat's a tasty treat but too much can give you cancer
Recent research from China has found that a diet of just 100 grams of red meat per day increases the risk of stomach cancer by 17%. The department of health recommends a diet consisting of only 65 grams of cooked red meat per day.
June 3, 2014 - Positive tips for making chemotherapy a little less miserable
Positive tips for making chemotherapy a little less miserable.  Read these tips from Amanda Woodward who receives her chemotherapy at MD Anderson.
May 29, 2014 - H. pylori eradication failed to reduce risk for gastric cancer after resection

According to a trial held in Seoul, South Korea from 2005 to 2011 eradication of Helicobacter Pylori did not reduce the patients risk of developing stomach cancer. 901 patients with H. Pylori who had been treated with endoscopic resection for early gastric cancer or gastric dysplasia were used as a part of this trial.

May 19, 2014 - Food Consumer
Eating too much red meat like beef may increase risk of stomach cancer, a study released in the June 2014 issue of Journal of Cancer Research and Clinical Oncology suggests.  Population based case-control studies showed that high red meat consumption was associated with 58% increased risk of stomach cancer, compared with low consumption.
May 15, 2014 - News Medical

Scientists from the University of Granada have successfully created magnetic bacteria that could be added to foodstuffs and could, after ingestion, help diagnose diseases of the digestive system like stomach cancer. These important findings constitute the first use of a food as a natural drug and aid in diagnosing an illness, anywhere in the world.

May 4, 2014 - International Nurses Week 2014: Have You Thanked A Nurse For Their Hard Work?

The week of May 6 – May 12 each year is National Nurses Week in the U.S. Florence Nightingale, born in 1820, made a name for herself after taking charge of nursing British and allied soldiers in Turkey during the Crimean War. She worked hours upon hours, tending to soldiers day and night. She changed nursing from the verge of incompetency, widely influencing practices such as sanitation, military health, and hospital planning. To this day, many of her practices are still implemented in hospitals worldwide, and the nurses are just as hardworking too. In commemoration of them, International Nurses Week will begin on Tuesday, and end on Nightingale's birthday, May 12.

May 1, 2014 - Gastric Cancer

It is estimated that 22,220 new cases of gastric cancer will be diagnosed in the United States in the year 2014, with 10,990 deaths expected. Worldwide in 2012, gastric cancer developed in approximately 930,000 individuals annually, accounting for 10% of neoplastic deaths. If you or a loved one has been diagnosed with gastric cancer, this article breaks down a total overview of important information that you need to know.

January 22, 2014 - Cooking Up Cancer?

A growing body of research suggests that cooking meats over a flame is linked to cancer. Combusting wood, gas, or charcoal emits chemicals known as polycyclic aromatic hydrocarbons. Exposure to these so-called PAHs is known to cause skin, liver, stomach, and several other types of cancer in lab animals. Epidemiological studies link occupational exposure to PAHs to cancer in humans.

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