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Debbie's Dream Foundation: Curing Stomach Cancer Support Community

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Welcome Debbie's Dream Foundation: Curing Stomach Cancer
Debbie's Dream Foundation: Curing Stomach Cancer is dedicated to raising awareness about stomach cancer, advancing funding for research, and providing education and support internationally to patients, families, and caregivers. DDF seeks as its ultimate goal to make the cure for stomach cancer a reality. Visit our Contact Us Page
(954) 475-1200 Office
(855) 475-1200 Toll Free Hotline
Types of Stomach Cancer

Virtually all stomach cancers are adenocarcinomas, meaning that the cancer begins in the glandular tissue that lines the inside of the stomach. Adenocarcinomas are further classified as either intestinal or diffuse. This is important because the classification influences the treatment and outcome of the disease.

Types of Stomach Cancer

  • Proximal (Cardia) stomach cancer - Affects the upper part of the stomach and may extend up into the gastroesophageal junction.
  • Non-cardia stomach cancer - Affects any other parts of the stomach and may develop from prolonged periods of inflammation and irritation. This type of stomach cancer is commonly associated with chronic infection with Helicobacter pylori bacteria and and follows a step-by-step progression from chronic gastritis to malignancy. Environmental factors such as smoking, high salt intake, and alcohol consumption are all risk factors for this type of stomach cancer.
  • Diffuse stomach cancer - Grows within the stomach wall as scattered cells without forming a distinct tumor, does not begin with a pre-malignant condition, and does not appear to be related to environmental factors such as diet or smoking, although infection with Helicobacter pylori raises the risk of this disease as well. The most important factor in diffuse gastric cancer is a genetic mutation that silences a gene called E-cadherin. Approximately 50% of patients with this type of stomach cancer have this gene mutation. There is also a hereditary form of diffuse gastric cancer (HDGC) which is caused by the loss of function in the CDH1 gene. People with this syndrome have a very high risk of stomach cancer.

Other Cancers of the Stomach

  • Gastrointestinal stromal tumor (GIST) - Abnormal growth of the connective tissues of the stomach wall
  • Lymphoma - Uncontrolled growth of the immune cells of the stomach
  • Carcinoid tumors - cancer of the hormone-producing cells of the stomach
  • Linitis Plastica - a rare type of stomach cancer that begins in the lining of the stomach and spreads to the muscles of the stomach wall. This causes the wall of the stomach to become thick, hard, and rubbery, which leads to trouble digesting food. This is also called gastric scirrhous carcinoma.
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